4-Nitrophenylhydrazine

4-硝基苯肼

What is 4-Nitrophenylhydrazine, cas no:100-16-3,a producer telling you the result.

                                            CAS NO.100-16-3

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To begin with, let us tell you what is the basic information of 4-Nitrophenylhydrazine ?

Molecular Formula

C6H7N3O2

Molecular Weight

153.139

Density

1.4±0.1 g/cm3

Boiling Point

344.0±25.0 °C at 760 mmHg

Flash Point

161.8±23.2 °C

Melting Point

156 °C (dec.)(lit.)

Like many stuff, it has many synonyms as follows

EINECS 202-824-8

MFCD00007579

Hydrazine, (4-nitrophenyl)-

(4-Nitrophenyl)hydrazine

4-Nitrophenylhydrazine

4-Nitropheylhydrazine

(p-Nitrophenyl)hydrazine

First, the chemical is very special, some technical indexes as below

 

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Physical property data

1. Appearance: Orange yellow crystalline powder [1]

2. Melting point (): 156 (decomposition) [2]

3. Octanol/water partition coefficient: 1.41 [3]

4. Solubility: Slightly soluble in water, soluble in hot water, benzene, ethanol, ether, chloroform, and ethyl acetate. [4]

toxicology data

1. Acute toxicity: LDLo in mouse peritoneal cavity: 250mg/kg;

2. Mutability: Microbial mutation test: bacteria Salmonella typhimurium, 50 μ g/plate; Mutation Microbial Test: Microbial, 780 μ g/L.

3. There is currently no data available on acute toxicity

4. There is currently no data available on irritability

5. Other [5] LDLo: 250mg/kg (mouse abdominal cavity)

Ecological data

1. There is currently no information on ecological toxicity

2. There is currently no data available on biodegradability

3. There is currently no information available on non biodegradable materials

Molecular structure data

1. Molar refractive index: 41.31

2. Molar volume (cm3/mol): 107.9

3. Waiting for Zhang Biarong (90.2K): 310.8

4. Surface tension (dyne/cm): 68.9

5. Dielectric constant:

6. Polarization distance (10-24cm3):

7. Polarization rate: 16.37

Calculate chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 2

3. Number of hydrogen bond acceptors: 4

4. Number of rotatable chemical bonds: 1

5. Number of tautomers: None

6. Topological molecule polarity surface area 83.9

7. Number of heavy atoms: 11

8. Surface charge: 0

9. Complexity: 137

10. Number of isotopic atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Nature and stability

1. Stability [6] Stability

2. Prohibited compounds [7] Strong oxidizing agents, strong reducing agents, strong acids

3. Conditions to avoid contact [8] Friction, vibration, or impact

4. Aggregation hazard [9] Non aggregation

5. Decomposition products [10] Nitrogen oxides

Storage method

Storage precautions [11] Store in a cool and ventilated warehouse. Stay away from sources of fire and heat. Sealed packaging. It should be stored separately from oxidants, reducing agents, acids, and edible chemicals, and avoid mixing storage. Equip with corresponding types and quantities of fire-fighting equipment. The storage area should be equipped with suitable materials to contain leaked materials.

 

 

Second, the Synthetic Route we will recommend is the most important for your reference?

First, synthesis line of 4-Nitrophenylhydrazine CAS NO.100-16-3  as follows

Main production methods:

Dissolve p-nitroaniline in hydrochloric acid, cool to 0 , add sodium nitrite solution for diazotization, and filter. Add the filtrate to a cooled mixture of sodium sulfite and sodium hydroxide, then add concentrated hydrochloric acid to make it acidic. Warm it at 25 for half an hour and filter to obtain p-nitrophenylhydrazine hydrochloride. Dissolve in water and add sodium acetate deep solution to precipitate p-nitrophenylhydrazine with a yield of 63-72%.

 

Third, what is the usage of  4-Nitrophenylhydrazine  CAS NO.100-16-3  pleas see below

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Main usages: Used as a reagent for testing ketones, aldehydes, and sugars.

 

Other usages:

Used for the synthesis of 3-(4-nitrophenyl)pyridine  Cas no. 4282-46-6

Used for the synthesis of 4-Nitrobenzeneazomalononitrile Cas no. 1080-02-0

Used for the synthesis of nitrobenzene Cas no. 98-95-3

Besides Safety Information of 4-Nitrophenylhydrazine  CAS NO.100-16-3  is also important when handling it

 

Hazard Codes 

Xi

WGK Germany 

3

HSCode

2928 0000.90

TSCA 

Yes

HazardClass 

IRRITANT

 

 

What is the appearance of 4-Nitrophenylhydrazine  CAS NO.100-16-3?   Please see the picture of 4-Nitrophenylhydrazine  CAS NO.100-16-3, below

 

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Specification of 4-Nitrophenylhydrazine  CAS NO.100-16-3, is below

Apperance:  Orange yellow crystalline powder

Assay: 99% min by HPLC

IR identity: conform

Melting point: 156 to 157 °C

 

IR  picture of  4-Nitrophenylhydrazine  CAS NO.100-16-3   is as follows,

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HNMR Spectrum  picture of  4-Nitrophenylhydrazine  CAS NO.100-16-3   is as follows,

 

Reference of  Article cited for your reference below,

(1)

Durchflussunterstützte Synthese von Heterocyclen bei hohen Temperaturen

Publication Name: Flow-Chemie für die Synthese von Heterocyclen

Publication Date: 2024

DOI: 10.1007/978-3-031-51912-3_4

(2)

A highly selective fluorescent probe for the detection of exogenous and endogenous hypochlorous acid/hypochlorite

Publication Name: Chemical Papers

Publication Date: 2022-12-09

DOI: 10.1007/s11696-022-02618-x

(3)

Kinetics of exothermal decomposition of 2-nitrophenylhydrazine and 4-nitrophenylhydrazine using DSC non-isothermal data

Publication Date: 2007

Publication Name: Journal of Thermal Analysis and Calorimetry