1-(2-Hydroxyethyl)-4-methylpiperazine

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What is 1-(2-Hydroxyethyl)-4-methylpiperazine, cas no:5464-12-0,a producer telling you the result.

                                            CAS NO.5464-12-0

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To begin with, let us tell you what is the basic information of 1-(2-Hydroxyethyl)-4-methylpiperazine ?

Molecular Formula

C7H16N2O

Molecular Weight

144.215

Density

1.0±0.1 g/cm3

Boiling Point

234.9±20.0 °C at 760 mmHg

Flash Point

106.1±20.4 °C

Melting Point

39-41°C

Like many stuff, it has many synonyms as follows

MFCD03840691

N-(2-Hydroxyethyl)-N'-methylpiperazine

1-Piperazineethanol, 4-methyl-

2-(4-methylpiperazin-1-yl)ethanol

2-(4-Methyl-1-piperazinyl)ethanol

1-(N-hydroxyethyl)-4-methyl piperazine

 

First, the chemical is very special, some technical indexes as below

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Molecular structure data

1. Molar refractive index: 41.14

2. Molar volume (cm3/mol): 143.6

3. Waiting ratio (90.2K): 350.4

4. Surface tension (dyne/cm): 35.4

5. Polarization rate (10-24cm3): 16.31

Calculate chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): -0.6

2. Number of hydrogen bond donors: 1

3. Number of hydrogen bond acceptors: 3

4. Number of rotatable chemical bonds: 2

5. Number of tautomers: None

6. Topological molecular polarity surface area 26.7

7. Number of heavy atoms: 10

8. Surface charge: 0

9. Complexity: 89.6

10. Number of isotopic atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Second, the Synthetic Route we will recommend is the most important for your reference?

First, synthesis line of 1-(2-Hydroxyethyl)-4-methylpiperazine CAS NO.5464-12-0  as follows

The main method of manufacture

  1. (2-hydroxyethyl) -4-methylpiperazine can be synthesized by various methods, among which the commonly used method is to react 4-methylpiperazine with ethoxyvinyl ammonium chloride to obtain

Third, what is the usage of  1-(2-Hydroxyethyl)-4-methylpiperazine  CAS NO.5464-12-0  pleas see below

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Usage:

1- (2-hydroxyethyl) -4-methylpiperazine is widely used in the pharmaceutical industry.

 

Other usage:

Used for the synthesis of 3-methoxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzaldehyde, Cas no. 646071-39-8

Used for the synthesis of 4-[2-(4-Methyl-1-piperazinyl)ethoxy]aniline Cas no. 38948-28-6

Used for the synthesis of 2-(4-methylpiperazin-1-yl)ethyl 1-cyclohexylcyclohexane-1-carboxylate Cas no. 3563-46-0

 

Besides Safety Information of 1-(2-Hydroxyethyl)-4-methylpiperazine  CAS NO.5464-12-0  is also important when handling it

 

 

Hazard Codes 

Xi

WGK Germany 

3

HSCode

2933599090

TSCA 

Yes

HazardClass 

IRRITANT

 

 

What is the appearance of 1-(2-Hydroxyethyl)-4-methylpiperazine  CAS NO.5464-12-0?   Please see the picture of 1-(2-Hydroxyethyl)-4-methylpiperazine  CAS NO.5464-12-0, below

 

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Specification of 1-(2-Hydroxyethyl)-4-methylpiperazine  CAS NO.5464-12-0, is below

Apperance: colorless to light yellow liquid.

Assay: 99 min by GC

IR identity: conform

Water:0.5% max by K.F.

C-HMR  picture of  1-(2-Hydroxyethyl)-4-methylpiperazine  CAS NO.5464-12-0   is as follows,

 

Reference of  Article cited for your reference below,

(1)

Characterization of the volatile profile of unifloral honey from Kashmir Valley of India by using solid-phase microextraction and gas chromatography–mass spectrometry

Publication Name: European Food Research and Technology

Publication Date: 2015-01-18

DOI: 10.1007/s00217-015-2413-2

(2)

Characterization of the volatile profile of unifloral honey from Kashmir Valley of India by using solid-phase microextraction and gas chromatography–mass spectrometry

Publication Date: 2015

Publication Name: European Food Research and Technology

(3)

Structure-Guided Discovery of Selective Mcl-1 Inhibitors

DOI: 10.1055/s-0039-1690939

Publication Date: 2019

Publication Name: Synfacts