1-Hydroxyethoxyethylpiperazine

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What is 1-Hydroxyethoxyethylpiperazine, cas no:13349-82-1,a producer telling you the result.

CAS NO.13349-82-1

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To begin with, let us tell you what is the basic information of 1-Hydroxyethoxyethylpiperazine ?

Molecular Formula	C8H18N2O2	Molecular Weight	174.241
Density	1.0±0.1 g/cm3	Boiling Point	305.7±0.0 °C at 760 mmHg
Flash Point	132.2±23.2 °C	Exact Mass	174.136826

Like many stuff, it has many synonyms as follows

MFCD00074931

Quetiapine Impurity 44

Ethanol, 2-[2-(1-piperazinyl)ethoxy]-

1-Hydroxyethoxyethylpiperazine

N-HYDROXYETHOXYETHYL PIPERAZINE

Quetiapine intermediate

2-[2-(1-Piperazinyl)ethoxy]ethanol

1-[2-(2-Hydroxyethoxy)ethyl]piperazine

T6M DNTJ D2O2Q

2-(2-(Piperazin-1-yl)ethoxy)ethanol

1-piperazidine

1-[2-(2-HYDROXYETHOXY)-ETHYL] PIPERAZINE

HEP

First, the chemical is very special, some technical indexes as below

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Physical property data

1. Characteristic: undetermined

2. Density (g/mL, 25/4 ℃): 1.061

3. Relative vapor density (g/mL, air=1): not determined

4. Melting point (º C): undetermined

5. Boiling point (º C, atmospheric pressure): 112-114 (33Pa)

6. Boiling point (º C, 5.2kPa): undetermined

7. Refractive index: n20/D 1.497

8. Flash point (º C):>110

9. Specific rotation (º): not determined

10. Spontaneous combustion point or ignition temperature (º C): not determined

11. Vapor pressure (kPa, 25 º C): not determined

12. Saturated vapor pressure (kPa, 60 º C): not determined

13. Combustion heat (KJ/mol): undetermined

14. Critical temperature (º C): not determined

15. Critical pressure (KPa): undetermined

16. Logarithmic value of oil-water (octanol/water) partition coefficient: undetermined

17. Explosion upper limit (%, V/V): undetermined

18. Lower explosive limit (%, V/V): not determined

19. Solubility: undetermined

toxicology data

Currently unavailable.

Ecological data

Currently unavailable

Molecular structure data

1. Molar refractive index: 47.23

2. Molar volume (m3/mol): 168.0

3. Waiting for Zhang Biarong (90.2K): 412.7

4. Surface tension (dyne/cm): 36.4

5. Polarization rate (10-24cm3): 18.72

6. Boiling point 112-114 ℃ (33Pa)

7. Density 1.061

Calculate chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): -1.2

2. Number of hydrogen bond donors: 2

3. Number of hydrogen bond acceptors: 4

4. Number of rotatable chemical bonds: 5

5. Number of tautomers: None

6. Topological molecular polarity surface area 44.7

7. Number of heavy atoms: 12

8. Surface charge: 0

9. Complexity: 105

10. Number of isotopic atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Second, the Synthetic Route we will recommend is the most important for your reference?

First, synthesis line of 1-Hydroxyethoxyethylpiperazine CAS NO.13349-82-1 as follows

Obtained by condensation of piperazine with chloroethoxyethanol. Add hexahydrate piperazine and hydrochloride piperazine into the reaction pot, stir and heat to 140 ℃, evaporate the water, and obtain piperazine hydrochloride. Cool to 120 ℃ and add chloroethoxyethanol dropwise. After adding, heat up to 150-155 ℃ and react for 4 hours. Place it in cold ethanol while still hot and cool to 0-5 ℃. Filter, neutralize the filtrate with sodium hydroxide solution, filter out sodium chloride, evaporate ethanol to obtain the finished product. The yield is 60%.

Third, what is the usage of 1-Hydroxyethoxyethylpiperazine CAS NO.13349-82-1 ? pleas see below

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Main usage：Intermediate of the weak stabilizing drug hydroxyzine.

Other usage:

Used for the synthesis of [4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]-(2-iodophenyl)methanone Cas no. 848814-26-6

Used for the synthesis of Quetiapine Cas no. 111974-69-7

Used for the synthesis of Isopropanol Cas no. 67-63-0

Besides Safety Information of 1-Hydroxyethoxyethylpiperazine CAS NO.13349-82-1 is also important when handling it

Hazard Codes	Xi
WGK Germany	3
H．S．Code：	2933 5990.99
TSCA	Yes
HazardClass	IRRITANT

What is the appearance of 1-Hydroxyethoxyethylpiperazine CAS NO.13349-82-1? Please see the picture of 1-Hydroxyethoxyethylpiperazine CAS NO.13349-82-1, below