1,4-Bis(2-hydroxyethyl)piperazine

CAS NO.122-96-3

What is 1,4-Bis(2-hydroxyethyl)piperazine, cas no:122-96-3,a producer telling you the result.

CAS NO.122-96-3

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To begin with, let us tell you what is the basic information of 1,4-Bis(2-hydroxyethyl)piperazine ?

Molecular Formula	C8H18N2O2	Molecular Weight	174.241
Density	1.1±0.1 g/cm3	Boiling Point	305.7±0.0 °C at 760 mmHg
Flash Point	166.2±22.4 °C	Melting Point	133.5-136 °C(lit.)

Like many stuff, it has many synonyms as follows

MFCD00006157

EINECS 204-586-0

1,4-Piperazinediethanol

N,N′-Bis(2-hydroxyethyl)piperazine

2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanol

2,2'-(Piperazine-1,4-diyl)diethanol

2,2'-(1,4-Piperazinediyl)diethanol

2,2'-piperazine-1,4-diyldiethanol

N,N'-Bis(β-hydroxyethyl)piperazine

First, the chemical is very special, some technical indexes as below

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toxicology data

1. Skin/Eye Irritation: Rabbit Skin Irritation Test: 10mg/24h has slight irritation to the skin.

2. Acute toxicity: Oral LD50 in rats: 3730mg/kg

Rabbit skin LD50:>10mL/kg

Ecological data

Currently unavailable

Molecular structure data

1. Molar refractive index: 47.30

2. Molar volume (m3/mol): 158.7

3. Waiting ratio (90.2K): 407.5

4. Surface tension (dyne/cm): 43.4

5. Polarization rate (10-24cm3): 18.75

Calculate chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): -1.3

2. Number of hydrogen bond donors: 2

3. Number of hydrogen bond acceptors: 4

4. Number of rotatable chemical bonds: 4

5. Number of tautomers: None

6. Topological molecule polarity surface area 46.9

7. Number of heavy atoms: 12

8. Surface charge: 0

9. Complexity: 99.6

10. Number of isotopic atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Second, the Synthetic Route we will recommend is the most important for your reference?

First, synthesis line of 1,4-Bis(2-hydroxyethyl)piperazine CAS NO.122-96-3 as follows

Manufacturing method:

There are two main methods for preparing N, N '- Bis (2-hydroxyethyl) piperazine. One method is to react ethylene glycol with piperazine under acidic conditions to obtain the product. Another method is to condense ethylene glycol with piperazine in the presence of an alkaline catalyst.

Third, what is the usage of 1,4-Bis(2-hydroxyethyl)piperazine CAS NO.122-96-3 ? pleas see below

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Usage:

The main use of N ' N - Bis (2-hydroxyethyl) piperazine is as an insecticide and acaricide. It can be used in agriculture, horticulture, and household hygiene fields to prevent and control various pests and mites, such as leaf rollers, whiteflies, red spider mites, etc.

Other usage:

Used for the synthesis of 1,4-Bis(2-chloroethyl)piperazine Cas no. 1009-85-4

Used for the synthesis of DABCO Cas no. 280-57-9

Besides Safety Information of 1,4-Bis(2-hydroxyethyl)piperazine CAS NO.122-96-3 is also important when handling it

Hazard Codes	Xi
WGK Germany	3
H．S．Code：	2933 3990.99
TSCA	Yes
HazardClass	IRRITANT

What is the appearance of 1,4-Bis(2-hydroxyethyl)piperazine CAS NO.122-96-3? Please see the picture of 1,4-Bis(2-hydroxyethyl)piperazine CAS NO.122-96-3, below

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Specification of 1,4-Bis(2-hydroxyethyl)piperazine CAS NO.122-96-3, is below

Apperance: white crystal powder

Assay: 99 min by HPLC

IR identity: conform

Water:0.5% max by K.F.

HNMR picture of 1,4-Bis(2-hydroxyethyl)piperazine CAS NO.122-96-3 is as follows,

IR picture of 1,4-Bis(2-hydroxyethyl)piperazine CAS NO.122-96-3 is as follows,

Reference of Article cited for your reference below,

(1)

Novel Biocompatible Hydrogels via Click Chemistry

Publication Name: Gels Horizons: From Science to Smart Materials

Publication Date: 2021

DOI: 10.1007/978-981-15-7138-1_16

(2)

Poly(amino carbonate urethane)-based biodegradable, temperature and pH-sensitive injectable hydrogels for sustained human growth hormone delivery

PMID: 27436576

Publication Date: 2016

Publication Name: Scientific Reports

(3)

Polyatomic anion versus acetonitrile in coordinating ability: structural properties of AgX-bearing 1,4-bis(2-isonicotinoyloxyethyl)piperazine (X− = NO3 −, CF3SO3 −, ClO4 −, BF4 −, and PF6 −)

Publication Date: 2011

Publication Name: Transition Metal Chemistry