4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol

What is 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol, cas no. 184475-71-6,a producer telling you the result.

                                                                CAS NO. 184475-71-6

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To begin with, let us tell you what is the basic information of 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol CAS NO. 184475-71-6 ?

Like many stuff, it has many synonyms as follows

First, the chemical is very special, some technical indexes as below

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Second, the Synthetic Route we will recommend is the most important for your reference?

First, synthesis line of 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol CAS NO. 184475-71-6  as follows

Manufacture method:

-The preparation method of 4- (3-chloro-4-fluoroaniline) -7-methoxy-quinazolin-6-ol usually includes the following steps:

1. Using appropriate reaction conditions, react 3-chloro-4-fluoroaniline with 7-methoxy-quinazolin-6-ol to generate the target compound.

2. Perform crystallization and purification steps to obtain single crystals of the target compound.

Third, what is the usage of  4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol  CAS NO. 184475-71-6 ?  pleas see below

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Usage:

184475-71-6 is a chemical substance with a purity of 99%, mainly used as an intermediate in the preparation of gefitinib. Gefitinib is a medication used to treat certain types of cancer. This compound, 4- (3-chloro-4-fluorophenylamino) -7-methoxyquinazolin-6-ol, is a key component in the synthesis of gefitinib. Its molecular formula is C15H11ClFN3O2, and its appearance is a light brown to off white powder. In addition, this compound is also used to supply gefitinib API (active pharmaceutical ingredient) and intermediates, demonstrating its important position in drug development and production.

Other usages as below

Used for the synthesis of Gefitinib Cas no. 184475-35-2

Used for the synthesis of N-(3-Chloro-4-fluorophenyl)-6-(3-chloropropoxy)-7-methoxyquinazolin-4-amine  Cas no. 912556-91-3

Used for the synthesis of 6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one  Cas no. 179688-52-9

Besides Safety Information of 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol  CAS NO.184475-71-6  is also important when handling it

What is the appearance of 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol  CAS NO.184475-71-6?   Please see the picture of 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol  CAS NO.184475-71-6, below

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Specification of 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol  CAS NO.184475-71-6, is below

Appearance: white or white like crystalline substance

Solubility: It is soluble in most organic solvents such as ethanol,

dimethylformamide, and chlorinated hydrocarbons at room temperature.

Assay:99% min by GC.

IR Identity: conform.

HNMR  picture of  4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol  CAS NO.184475-71-6   is as follows,

Reference of  Article cited for your reference below,

(1)

Egfr protein degradant and anti-tumor application thereof

Publication Number: US-2022313829-A1

Priority Date: 2019-08-05

(2)

A kind of isoindolinone-containing quinazoline-based carboxylate derivatives and application thereof

Publication Number: CN-112125890-B

Priority Date: 2020-09-25

Grant Date: 2022-12-06