5-Fluoro-2-oxindole

5-Fluoro-1,3-dihydro-2H-indol-2-one

What is 5-Fluoro-2-oxindole, cas no. 56341-41-4,a producer telling you the result.

                                                                CAS NO. 56341-41-4

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To begin with, let us tell you what is the basic information of 5-Fluoro-2-oxindole CAS NO. 56341-41-4 ?

Molecular Formula

C8H6FNO

Molecular Weight

151.14

Density

1.3±0.1 g/cm3

Boiling Point

307.2±42.0 °C at 760 mmHg

Flash Point

139.6±27.9 °C

Melting Point

143-147 °C(lit.)

 

Like many stuff, it has many synonyms as follows

MFCD02179598

5-Fluorooxindole

EINECS 446-540-4

5-FLUROOXINDOLE

T56 BMV DHJ GF

Fluorooxindole

5-Fluoro-2-oxindole

5-fluoro-2-oxo-1,2-dihydro-indole

5-Fluoro-1,3-dihydro-2H-indol-2-one

5-Fluoro-1,3-dihydro-indol-2-one

5-Fluoroindole-2-One

5-FLUORO-2-OXYINDOLE

2H-Indol-2-one, 5-fluoro-1,3-dihydro-

5-fluoroindolin-2-one

5-Fluoro-2-indolinone

5-Fluoro-1,3-dihydroindol-2-one

First, the chemical is very special, some technical indexes as below

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Physical property data

1. Characteristic: None available

2. Density (g/mL, 25/4 ): not available

3. Relative vapor density (g/mL, air=1): unavailable

4. Melting point (º C): 143-147

5. Boiling point (º C, atmospheric pressure): not available

6. Boiling point (º C, 5.2kPa): not available

7. Refractive index: not available

8. Flash point (º C): not available

9. Specific rotation (º): not available

10. Spontaneous combustion point or ignition temperature (º C): not available

11. Vapor pressure (kPa, 25 º C): not available

12. Saturated vapor pressure (kPa, 60 º C): not available

13. Combustion heat (KJ/mol): not available

14. Critical temperature (º C): not available

15. Critical pressure (KPa): not available

16. Logarithmic value of oil-water (octanol/water) partition coefficient: not available

17. Explosion upper limit (%, V/V): not available

18. Lower explosive limit (%, V/V): not available

19. Solubility: None available

Security information:

-Under normal operating conditions, 5-fluoroindole-2-one is generally non-toxic to the human body. Any chemical substance should follow safe operating procedures, including wearing appropriate personal protective equipment and avoiding contact with skin, eyes, and mucous membranes. If accidentally inhaled or ingested, seek medical attention as soon as possible

Ecological data

This substance may be harmful to the environment and should be given special attention to water bodies.

Molecular structure data

1. Molar refractive index: 37.28

2. Molar volume (cm3/mol): 115.2

3. Waiting for Zhang Biarong (90.2K): 293.2

4. Surface tension (dyne/cm): 41.8

5. Polarization rate: 14.78

6. Dielectric constant: undetermined

Calculate chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 1

3. Number of hydrogen bond acceptors: 2

4. Number of rotatable chemical bonds: 0

5. Number of tautomers: 3

6. Topological molecular polarity surface area 29.1

7. Number of heavy atoms: 11

8. Surface charge: 0

9. Complexity: 183

10. Number of isotopic atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Nature and stability

If used and stored according to regulations, it will not decompose.

Storage method

Keep the storage container sealed

Put it in a tight storage container and store it in a cool, dry place

 

Second, the Synthetic Route we will recommend is the most important for your reference?

First, synthesis line of 5-Fluoro-2-oxindole CAS NO. 56341-41-4  as follows

Manufacturing method:

-5-fluoroindole-2-one can usually be synthesized by reacting fluorine gas with indole-2-one. The specific synthesis method can be carried out using fluorinating reagents and catalysts.

 

Third, what is the usage of  5-Fluoro-2-oxindole  CAS NO. 56341-41-4  pleas see below

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Main usages:

-Chemical synthesis: 5-fluoroindole-2-one is commonly used as an important intermediate in organic synthesis and can be used to synthesize organic compounds such as indole and fluorescent dyes.

 

 

Other usages as below

 

Used for the synthesis of sunitinib Cas no. 557795-19-4

 

Used for the synthesis of  5-Fluoroindoline
 

Cas no. 2343-22-8

 

Used for the synthesis of Toceranib
 

,Cas no. 356068-94-5

 

 

Besides Safety Information of 5-Fluoro-2-oxindole  CAS NO.56341-41-4  is also important when handling it

 

Hazard Codes 

Xi

WGK Germany 

3

HSCode

2933990090

TSCA 

Yes

HazardClass 

IRRITANT

 

 

What is the appearance of 5-Fluoro-2-oxindole  CAS NO.56341-41-4?   Please see the picture of 5-Fluoro-2-oxindole  CAS NO.56341-41-4, below

 

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Specification of 5-Fluoro-2-oxindole  CAS NO.56341-41-4, is below

Apperance: light yellow crystal powder

Assay: 98 min  by HPLC

IR identity: conform

Water:0.5% max by K.F.

HNMR  picture of  5-Fluoro-2-oxindole  CAS NO.56341-41-4   is as follows,

IR  picture of  5-Fluoro-2-oxindole  CAS NO.56341-41-4   is as follows,

Reference of  Article cited for your reference below,

(1)

Selective rapid and optically switchable regulation of protein function in live mammalian cells.

PMID: 26100803

Publication Date: 2015

Publication Name: Nature Chemistry

(2)

Synthesis and in vitro antitumor activity of 1-(3-dimethylamino)propyl indolin-2-one derivatives

Publication Date: 2012

Publication Name: Medicinal Chemistry Research