5-Fluoro-2-oxindole
What is 5-Fluoro-2-oxindole, cas no. 56341-41-4,a producer telling you the result.
CAS NO. 56341-41-4
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To begin with, let us tell you what is the basic information of 5-Fluoro-2-oxindole CAS NO. 56341-41-4 ?
Molecular Formula |
C8H6FNO |
Molecular Weight |
151.14 |
Density |
1.3±0.1 g/cm3 |
Boiling Point |
307.2±42.0 °C at 760 mmHg |
Flash Point |
139.6±27.9 °C |
Melting Point |
143-147 °C(lit.) |
Like many stuff, it has many synonyms as follows
MFCD02179598 |
5-Fluorooxindole |
EINECS 446-540-4 |
5-FLUROOXINDOLE |
T56 BMV DHJ GF |
Fluorooxindole |
5-Fluoro-2-oxindole |
5-Fluoro-1,3-dihydro-2H-indol-2-one |
5-Fluoro-1,3-dihydro-indol-2-one |
5-Fluoroindole-2-One |
5-FLUORO-2-OXYINDOLE |
2H-Indol-2-one, 5-fluoro-1,3-dihydro- |
5-fluoroindolin-2-one |
5-Fluoro-2-indolinone |
5-Fluoro-1,3-dihydroindol-2-one |
First, the chemical is very special, some technical indexes as below
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Physical property data
1. Characteristic: None available
2. Density (g/mL, 25/4 ℃): not available
3. Relative vapor density (g/mL, air=1): unavailable
4. Melting point (º C): 143-147
5. Boiling point (º C, atmospheric pressure): not available
6. Boiling point (º C, 5.2kPa): not available
7. Refractive index: not available
8. Flash point (º C): not available
9. Specific rotation (º): not available
10. Spontaneous combustion point or ignition temperature (º C): not available
11. Vapor pressure (kPa, 25 º C): not available
12. Saturated vapor pressure (kPa, 60 º C): not available
13. Combustion heat (KJ/mol): not available
14. Critical temperature (º C): not available
15. Critical pressure (KPa): not available
16. Logarithmic value of oil-water (octanol/water) partition coefficient: not available
17. Explosion upper limit (%, V/V): not available
18. Lower explosive limit (%, V/V): not available
19. Solubility: None available
Security information:
-Under normal operating conditions, 5-fluoroindole-2-one is generally non-toxic to the human body. Any chemical substance should follow safe operating procedures, including wearing appropriate personal protective equipment and avoiding contact with skin, eyes, and mucous membranes. If accidentally inhaled or ingested, seek medical attention as soon as possible
Ecological data
This substance may be harmful to the environment and should be given special attention to water bodies.
Molecular structure data
1. Molar refractive index: 37.28
2. Molar volume (cm3/mol): 115.2
3. Waiting for Zhang Biarong (90.2K): 293.2
4. Surface tension (dyne/cm): 41.8
5. Polarization rate: 14.78
6. Dielectric constant: undetermined
Calculate chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): None
2. Number of hydrogen bond donors: 1
3. Number of hydrogen bond acceptors: 2
4. Number of rotatable chemical bonds: 0
5. Number of tautomers: 3
6. Topological molecular polarity surface area 29.1
7. Number of heavy atoms: 11
8. Surface charge: 0
9. Complexity: 183
10. Number of isotopic atoms: 0
11. Determine the number of atomic stereocenters: 0
12. Uncertain number of atomic stereocenters: 0
13. Determine the number of chemical bond stereocenters: 0
14. Number of uncertain chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Nature and stability
If used and stored according to regulations, it will not decompose.
Storage method
Keep the storage container sealed
Put it in a tight storage container and store it in a cool, dry place
Second, the Synthetic Route we will recommend is the most important for your reference?
First, synthesis line of 5-Fluoro-2-oxindole CAS NO. 56341-41-4 as follows
Manufacturing method:
-5-fluoroindole-2-one can usually be synthesized by reacting fluorine gas with indole-2-one. The specific synthesis method can be carried out using fluorinating reagents and catalysts.
Third, what is the usage of 5-Fluoro-2-oxindole CAS NO. 56341-41-4 ? pleas see below
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Main usages:
-Chemical synthesis: 5-fluoroindole-2-one is commonly used as an important intermediate in organic synthesis and can be used to synthesize organic compounds such as indole and fluorescent dyes.
Other usages as below
Used for the synthesis of sunitinib Cas no. 557795-19-4
Used for the synthesis of 5-Fluoroindoline
Cas no. 2343-22-8
Used for the synthesis of Toceranib
,Cas no. 356068-94-5
Besides Safety Information of 5-Fluoro-2-oxindole CAS NO.56341-41-4 is also important when handling it
Hazard Codes |
Xi |
WGK Germany |
3 |
H.S.Code: |
2933990090 |
TSCA |
Yes |
HazardClass |
IRRITANT |
What is the appearance of 5-Fluoro-2-oxindole CAS NO.56341-41-4? Please see the picture of 5-Fluoro-2-oxindole CAS NO.56341-41-4, below
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Specification of 5-Fluoro-2-oxindole CAS NO.56341-41-4, is below
Apperance: light yellow crystal powder
Assay: 98 min by HPLC
IR identity: conform
Water:0.5% max by K.F.
HNMR picture of 5-Fluoro-2-oxindole CAS NO.56341-41-4 is as follows,
IR picture of 5-Fluoro-2-oxindole CAS NO.56341-41-4 is as follows,
Reference of Article cited for your reference below,
(1)
Selective rapid and optically switchable regulation of protein function in live mammalian cells.
PMID: 26100803
Publication Date: 2015
Publication Name: Nature Chemistry
(2)
Synthesis and in vitro antitumor activity of 1-(3-dimethylamino)propyl indolin-2-one derivatives
Publication Date: 2012
Publication Name: Medicinal Chemistry Research