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2-Aminothiazol-4-acetic acid

What is 2-Aminothiazol-4-acetic acid, cas no. 29676-71-9,a producer telling you the result.

What is 2-Aminothiazol-4-acetic acid, cas no. 29676-71-9,a producer telling you the result.

                                                                CAS NO. 29676-71-9

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To begin with, let us tell you what is the basic information of 2-Aminothiazol-4-acetic acid CAS NO. 29676-71-9 ?

Flash Point

195.1±20.9 °C

Molecular Weight

158.178

Density

1.6±0.1 g/cm3

Boiling Point

399.0±17.0 °C at 760 mmHg

Molecular Formula

C5H6N2O2S

Melting Point

130 °C (dec.)(lit.)

EINECS No.

249-769-6

MDL NO.

MFCD000100682

 

Like many stuff, it has many synonyms as follows

(2-Aminothiazole-4-yl)acetic acid

2-(2-Aminothiazol-4-yl)acetic acid

-Aminothiazol-4-acetic acid

2-aminothiazole-4-acetic acid

2-Amino-4-thiazoleacetic acid

(2-Aminothiazole-4-YL)-Acetic Acid

(2-Amino-4-thiazolyl)acetic Acid

(2-ammonio-1,3-thiazol-4-yl)acetate

4-thiazoleacetic acid, 2,3-dihydro-2-imino-

(2-Imino-2,3-dihydro-1,3-thiazol-4-yl)acetic acid

(2-Amino-1,3-thiazol-4-yl)acetic acid

4-Thiazoleacetic acid, 2-amino-
（2-AMINO THIAZOLE-4-YL) ACETIC ACID

 

First, the chemical is very special, some technical indexes as below

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Physical property data

1. Appearance: White or light brown powder

2. Density (g/mL, 20 ℃): undetermined

3. Relative vapor density (g/mL, air=1): not determined

4. Melting point (º C): 130

5. Boiling point (º C, atmospheric pressure): undetermined

6. Boiling point (º C, KPa): undetermined

7. Refractive index: undetermined

8. Flash point (º C): undetermined

9. Specific rotation (º): not determined

10. Spontaneous combustion point or ignition temperature (º C): not determined

11. Vapor pressure (Pa, 20 º C): not determined

12. Saturated vapor pressure (KPa, 25 º C): not determined

13. Combustion heat (KJ/mol): undetermined

14. Critical temperature (º C): not determined

15. Critical pressure (KPa): undetermined

16. Logarithmic value of oil-water (octanol/water) partition coefficient: undetermined

17. Explosion upper limit (%, V/V): undetermined

18. Lower explosive limit (%, V/V): not determined

19. Solubility: Water: 20 º C, 6.5g/L

toxicology data

Currently unavailable

Ecological data

Usually, it is slightly harmful to water. Do not discharge materials into the surrounding environment without government permission.

Molecular structure data

Currently unavailable

Calculate chemical data

1. Hydrophobic parameter calculation reference value (XlogP): 0.1

2. Number of hydrogen bond donors: 2

3. Number of hydrogen bond acceptors: 4

4. Number of rotatable chemical bonds: 2

5. Number of tautomers: 2

6. Topological Molecular Polarity Surface Area (TPSA): 76.2

7. Number of heavy atoms: 10

8. Surface charge: 0

9. Complexity: 142

10. Number of isotopic atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Uncertain number of chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Nature and stability

If used and stored according to specifications, it will not decompose and there are no known hazardous reactions

Avoid oxides

Storage method

Sealed and refrigerated storage

 

Second, the Synthetic Route we will recommend is the most important for your reference?

First, synthesis line of 2-Aminothiazol-4-acetic acid CAS NO. 29676-71-9  as follows

Main synthetic route:

Chloroacetyl or bromoacetyl ethyl acetate with thiourea condensation: Firstly, chloroacetyl or bromoacetyl ethyl acetate undergoes a condensation reaction with thiourea. ‌

Hydrolysis: The condensation product is then subjected to hydrolysis reaction, ultimately yielding 2-aminothiazole-4-acetic acid 1. ‌

This is the main synthesis method of the compound, used in the manufacture of cephalosporin drugs, especially as intermediate 1 of cefotaxime. ‌

Please note that specific synthesis conditions (such as temperature, pressure, catalyst, etc.) may vary due to laboratory conditions or process requirements. Therefore, in practical operation, relevant chemical literature or professional guidance should be consulted to ensure the safety and effectiveness of the synthesis process. ‌

In addition, due to the complex reaction processes and potential hazards involved in chemical synthesis, non professionals should operate under the guidance of professionals and strictly comply with relevant safety operating procedures and laws and regulations

 

Third, what is the usage of  2-Aminothiazol-4-acetic acid CAS NO. 29676-71-9 ?  pleas see below

 

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The purpose of 29676-71-9 is for the manufacture of cephalosporin drugs and is an intermediate of cefotaxime. ‌

29676-71-9, also known as aminothiazole acetic acid, is an important pharmaceutical and chemical intermediate. It has multiple aliases, including 2-amino-4-thiazoleacetic acid, 2-aminothiazol-4-acetic acid, ATAA, and 2- (2-aminothiazol-4-yl) acetic acid methyl ester. This compound plays a key role in the pharmaceutical field, especially in the manufacturing process of cephalosporin drugs, where it plays an indispensable role as an intermediate of cefotaxime. In addition, the melting point of the compound is 130 ° C, indicating its physical properties at specific temperatures, which is of great significance for its application in the pharmaceutical and chemical industry. ‌

In summary, 29676-71-9 not only has a wide range of applications in the pharmaceutical field, but also plays an important role in the production of cephalosporin drugs and is a key intermediate in the synthesis of cefotaxime

Other usages as below

 

Used for the synthesis of mirabegron

Cas no. 223673-61-8

 

Used for the synthesis of  2-[2-[(4-aminophenyl)sulfonylamino]-1,3-thiazol-4-yl]acetic acid

Cas no. 135285-81-3

Used for the synthesis of 2-[2-(tritylamino)-1,3-thiazol-4-yl]acetic acid
 

,Cas no. 64220-26-4

 

Besides Safety Information of 2-Aminothiazol-4-acetic acid CAS NO.29676-71-9  is also important when handling it

 

Hazard Codes 

Xi

WGK Germany 

3

H．S．Code：

2942 0000.00

TSCA 

Yes

HazardClass 

IRRITANT

 

 

What is the appearance of 2-Aminothiazol-4-acetic acid CAS NO.29676-71-9?   Please see the picture of 2-Aminothiazol-4-acetic acid CAS NO.29676-71-9, below

 

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Specification of 2-Aminothiazol-4-acetic acid CAS NO.29676-71-9, is below

Apperance: White to light brown powder

Assay: 98 min  by HPLC

IR identity: conform

Water:0.5% max by K.F.

IR  picture of  2-Aminothiazol-4-acetic acid CAS NO.29676-71-9   is as follows,

 

 

Reference of  Article cited for your reference below,

（1）

（2）

 

 

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