5-Chlorothiophene-2-carboxylic Acid

What is 5-Chlorothiophene-2-carboxylic Acid, cas no. 24065-33-6,a producer telling you the result.

What is 5-Chlorothiophene-2-carboxylic Acid, cas no. 24065-33-6,a producer telling you the result.

CAS NO. 24065-33-6

If you need the products .Please send your inquiry to us through e-mail： sales@yuansu-reagent.com

To begin with, let us tell you what is the basic information of 5-Chlorothiophene-2-carboxylic Acid CAS NO. 24065-33-6 ?

Molecular Weight	162.59	Molecular Formula	C5H3ClO2S
Density	1.6±0.1 g/cm3	Boiling Point	287.0±20.0 °C at 760 mmHg
Flash Point	127.4±21.8 °C	Melting Point	154-158 °C(lit.)

Like many stuff, it has many synonyms as follows

MFCD00041426

2-Thiophenecarboxylic acid, 5-chloro-

5-Chloro-2-thiophenecarboxylic acid

5-Chlorothiophene-2-carboxylic acid

5-chlorothiophene 2-carboxylic acid

5-Chlorothiophene-2-carboxylic

2-Thiophenecarboxylic acid,5-chloro

5-chlorothiophene-2-carboxylic acid acid

First, the chemical is very special, some technical indexes as below

If you need the products .Please send your inquiry to us through e-mail： sales@yuansu-reagent.com

Molecular structure data

1. Molar refractive index: 36.46

2. Molar volume (m3/mol): 103.3

3. Waiting ratio (90.2K): 288.4

4. Surface tension (dyne/cm): 60.5

5. Polarization rate (10-24cm3): 14.45

Calculate chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): 2.4

2. Number of hydrogen bond donors: 1

3. Number of hydrogen bond acceptors: 3

4. Number of rotatable chemical bonds: 1

5. Number of tautomers: None

6. Topological molecule polarity surface area 65.5

7. Number of heavy atoms: 9

8. Surface charge: 0

9. Complexity: 128

10. Number of isotopic atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Nature and stability

If used and stored according to specifications, it will not decompose

Avoid contact with oxides

Storage method

Keep the storage container sealed

Put it in a tight storage container and store it in a cool, dry place

Second, the Synthetic Route we will recommend is the most important for your reference?

First, synthesis line of 5-Chlorothiophene-2-carboxylic Acid CAS NO. 24065-33-6 as follows

Step 1: Preparation of 5-Chlorothiophene-2-aldehyde

Add 200 grams of N, N-dimethylformamide (DMF) and 118.5 grams (1.0 mole) of 2-chlorothiophene to a 1-liter dry four necked bottle equipped with stirring, thermometer, condenser, and constant pressure dropping funnel. Heat and maintain the internal temperature between 40-60 ℃. Slowly drop 169 grams (1.1 mole) of phosphorus oxychloride from the constant pressure dropping funnel. After dropping, stir at 95-100 ℃ for 2 hours. Cool to 20 ℃, pour the reaction solution into a beaker containing 400 grams of crushed ice and 400 grams of water, then neutralize with 30% sodium hydroxide solution to a pH of 6-7, separate the oil layer, extract the water layer with dichloromethane three times, each time using 300 grams of dichloromethane, combine the dichloromethane layer and the separated oil layer, wash the organic phase with 50 grams of water once, distill the organic phase to recover dichloromethane, and then vacuum distill to obtain 141.5 grams of 5-chlorothiophene-2-aldehyde, with a yield of 96.6% and a GC purity of 99.97%.

Step 2: Preparation of 2-chlorothiophene-5-carboxylic acid

Add 200 grams of dichloromethane, 29.5 grams (0.2 moles) of 5-chlorothiophene-2-aldehyde, 30 grams of 30% hydrogen peroxide, and stir at 25-30 degrees Celsius for 6 hours to a 500 milliliter four necked bottle with stirring and a thermometer. Layered, the aqueous layer was extracted three times with 50 grams of dichloromethane each time. The dichloromethane layers were combined, and the organic phase was washed once with 20 grams of a 5% sodium sulfite aqueous solution. The organic phase was distilled to recover dichloromethane, and the residue was recrystallized from petroleum ether to obtain 30.5 grams of white solid 2-chlorothiophene-5-carboxylic acid with a yield of 93.8% and HPLC purity of 99.98%.

Other synthesis lines as follows

Third, what is the usage of 5-Chlorothiophene-2-carboxylic Acid CAS NO. 24065-33-6 ? pleas see below

If you need the products .Please send your inquiry to us through e-mail： sales@yuansu-reagent.com

Mainly used for Used for low-cost preparation of high-purity 5-chlorothieno-2-formyl chloride

The method for preparing 2-chlorothiophene-2-carboxylic acid chloride using 2-chlorothiophene-5-carboxylic acid is as follows:

Add 100 grams of dichloromethane, 16.5 grams (0.1 mole) of 2-chlorothiophene-5-carboxylic acid, 1 drop of N, N-dimethylformamide, 15 grams of thionyl chloride, and stir at 40 degrees Celsius for 4 hours to a dry 250 milliliter four necked bottle connected to a stirring, thermometer, and alkali absorption system. Distillation was used to recover dichloromethane and excess thionyl chloride, followed by vacuum distillation (80-90 ℃/5 mmHg) to obtain 18.0 grams of colorless liquid 5-chlorothieno-2-formyl chloride with a yield of 100.0% and a GC purity of 99.98%.

Other usages as below

Used for the synthesis of 2-Chloro-thiophene-5-isocyanate, Cas no. 76537-13-8

Used for the synthesis of (5-Chloro-2-Thienyl)Acetic Acid Cas no. 13669-19-7

Used for the synthesis of 1-(5-chlorothiophen-2-yl)propan-1-one ,Cas no. 32427-82-0

Besides Safety Information of 5-Chlorothiophene-2-carboxylic Acid CAS NO. 24065-33-6 is also important when handling it

Hazard Codes	Xi
WGK Germany	3
H．S．Code：	2934 9990.99
TSCA	Yes
HazardClass	IRRITANT

What is the appearance of 5-Chlorothiophene-2-carboxylic Acid CAS NO. 24065-33-6? Please see the picture of 5-Chlorothiophene-2-carboxylic Acid CAS NO. 24065-33-6, below