5-Chlorothiophene-2-carboxylic Acid

What is 5-Chlorothiophene-2-carbonyl chloride, cas no. 42518-98-9,a producer telling you the result.

What is 5-Chlorothiophene-2-carbonyl chloride, cas no. 42518-98-9,a producer telling you the result.

                                                                CAS NO. 42518-98-9

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To begin with, let us tell you what is the basic information of 5-Chlorothiophene-2-carbonyl chloride CAS NO. 42518-98-9 ?

 

Molecular Weight

181.040

Flash Point

89.2±21.8 °C

Molecular Formula

C5H2Cl2OS

Boiling Point

223.9±20.0 °C at 760 mmHg

Density

1.5±0.1 g/cm3

Melting Point

4 °C

 

Like many stuff, it has many synonyms as follows

Rivaroxaban Impurity 82

5-Chloro-thiophene-2-carbonyl chloride

MFCD00043886

5-Chloro-2-thiophenecarbonyl chloride

2-Thiophenecarbonyl chloride, 5-chloro-

5-chlorothiophene-2-carbonyl chloride

5-Chloro-2-thenoyl Chloride

5-Chorothiophene-2-Carbonyl Chloride

First, the chemical is very special, some technical indexes as below

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Security information:

5-Chloro-2-acylchlorothiophene belongs to organic chlorinated compounds and has certain toxicity.

When handling and storing this compound, appropriate protective gloves, glasses, and protective clothing should be worn.

Avoid contact with skin, eyes, and respiratory tract to avoid irritation or damage.

During use, good ventilation should be maintained and contact with combustible materials should be avoided.

When handling waste, relevant safety operating procedures and regulations should be followed.

 

Second, the Synthetic Route we will recommend is the most important for your reference?

First, synthesis line of 5-Chlorothiophene-2-carbonyl chloride CAS NO. 42518-98-9 as follows

5-Chloro-2-acylchlorothiophene can be obtained by reacting 5-chloro-2-ketothiophene with thionyl chloride.

The reaction conditions are generally carried out in an inert atmosphere at lower temperatures.

 

Third, what is the usage of  5-Chlorothiophene-2-carbonyl chloride CAS NO. 42518-98-9  pleas see below

 

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5-Chloro-2-acylchlorothiophene is commonly used as a reagent in organic synthesis.

In the agricultural field, it is often used as an intermediate for insect insecticides.

 

Other usages as below

 

Used for the synthesis of  2-(5-chlorothiophen-2-yl)acetic acid   Cas no. 13669-19-7

 

Used for the synthesis of  1-(5-chlorothiophen-2-yl)propan-1-one Cas no. 32427-82-0

Used for the synthesis of 2-[(5-chlorothiophene-2-carbonyl)amino]-2-methylpropanoic acid ,Cas no. 869548-36-7

Besides Safety Information of 5-Chlorothiophene-2-carbonyl chloride CAS NO. 42518-98-9  is also important when handling it

 

Hazard Codes 

Xi

WGK Germany 

3

HSCode

2934999090

TSCA 

Yes

HazardClass 

IRRITANT

 

 

What is the appearance of 5-Chlorothiophene-2-carbonyl chloride CAS NO. 42518-98-9?   Please see the picture of 5-Chlorothiophene-2-carbonyl chloride CAS NO. 42518-98-9, below

 

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Specification of 5-Chlorothiophene-2-carbonyl chloride CAS NO. 42518-98-9, is below

Apperance: white to off-white crystal powder

Density: 1.543~1.544g/cm ³

Flash point: 89.2

Melting point: 151~155

Vapour pressure: 0.0937mmHg at 25

IR identity: conform

Water:0.5% max by K.F.

HNMR  picture of  5-Chlorothiophene-2-carbonyl chloride CAS NO. 42518-98-9 is as follows,

 

Reference of  Article cited for your reference below,

 

(1)

Comparison of the Hydrolysis and Esterification Methods for the Determination of Genotoxic 5-Chlorothiophene-2-Carbonyl Chloride in Rivaroxaban Using HPLC

Publication Name: Chromatographia

Publication Date: 2016-02-08

DOI: 10.1007/s10337-016-3038-8

(2)

Synthesis of Substituted Alkoxythiophenes: Thiophene Analogues of Dazoxiben

Publication Name: Monatshefte für Chemie / Chemical Monthly

Publication Date: 1999-05-01

DOI: 10.1007/pl00010245

(3)

Comparison of the Hydrolysis and Esterification Methods for the Determination of Genotoxic 5-Chlorothiophene-2-Carbonyl Chloride in Rivaroxaban Using HPLC

Publication Date: 2016

Publication Name: Chromatographia