Caronic anhydride

What is 6,6-Dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione, cas no. 67911-21-1,a producer telling you the result.

What is 6,6-Dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione, cas no. 67911-21-1,a producer telling you the result.

                                                                CAS NO. 67911-21-1

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To begin with, let us tell you what is the basic information of Caronic anhydride CAS NO. 67911-21-1 ?

Molecular Weight

140.137

Flash Point

112.7±15.9 °C

Density

1.3±0.1 g/cm3

Boiling Point

246.3±9.0 °C at 760 mmHg

Molecular Formula

C7H8O3

Melting Point

52-55ºC

Like many stuff, it has many synonyms as follows

6,6-Dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione

Caronic anhydride

3-oxabicyclo[3.1.0]hexane-2,4-dione, 6,6-dimethyl-

 

First, the chemical is very special, some technical indexes as below

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Second, the Synthetic Route we will recommend is the most important for your reference?

First, synthesis line of Caronic anhydride CAS NO. 67911-21-1  as follows

There are two routes for the synthesis of carbolic anhydride, and the first generation route requires 12 linear synthesis steps, which is costly.

The second generation route consists of three stages of synthesis, which involve benzylamine amination, reduction, and removal of benzyl groups to obtain carmonic anhydride.

Enzymatic catalysis is an application method in the synthesis of carmonic anhydride, which involves treating amines with oxidase and then treating them with sodium bisulfite to obtain the target compound

Synthesis lines in details as below

Third, what is the usage of  Caronic anhydride  CAS NO. 67911-21-1  pleas see below

 

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Caronic anhydride is an important compound with extensive application value.

Boprevir is a type of hepatitis C treatment drug, also known as Victrelis. Its molecular structure contains fragment P2.

Pfizer's COVID-19 oral drug Paxlovid also contains fragment P2, so the demand for carborunic anhydride also increases.

 

Mainly used for Intermediate of dabigatran ester

 

Other usages as below

 

Used for the synthesis of 3,3-Dimethylcyclopropane-1,2-dicarboximide

Cas no. 194421-56-2

 

Used for the synthesis of 6,6-dimethyl-3-azabicyclo[3.1.0]hexane,hydrochloride

Cas no. 943516-55-0

Used for the synthesis of
6,6-Dimethyl-3-azabicyclo[3.1.0]hexane

,Cas no. 943516-54-9

 

Besides Safety Information of Caronic anhydride  CAS NO. 67911-21-1  is also important when handling it

 

Hazard Codes 

Xi

WGK Germany 

3

HSCode

2917209090

TSCA 

Yes

HazardClass 

IRRITANT

 

 

What is the appearance of Caronic anhydride  CAS NO. 67911-21-1?   Please see the picture of Caronic anhydride  CAS NO. 67911-21-1, below

 

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Specification of Caronic anhydride  CAS NO. 67911-21-1, is below

Apperance: white to off-white crystal powder

Assay: 98 %~103%  by GC

IR identity: conform

Water:0.5% max by K.F.

Melting point:52~55

HNMR  picture of  Caronic anhydride  CAS NO. 67911-21-1   is as follows,

 

Reference of  Article cited for your reference below,

(1)

Modulators of G-protein coupled receptors

Publication Number: KR-20210008834-A

Priority Date: 2018-03-23

(2)

Process and intermediates for the preparation of (1r,2s,5s)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof

EP-1633711-B1; Grant Date: 2010-11-24

(3)

Compounds, pharmaceutically acceptable salts thereof, use of compounds and pharmaceutical compositions.

JP-6986789-B2; Grant Date: 2021-12-22