2-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

  CAS NO. 141645-16-1

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To begin with, let us tell you what is the basic information of 2-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran CAS NO. 141645-16-1?

Like many stuff, it has many synonyms as follows

First, the chemical is very special, some technical indexes as below

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Second, the Synthetic Route we will recommend is the most important for your reference?

First, synthesis line of 2-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran CAS NO. 141645-16-1 as follows

The preparation of 2-butyl-3- (4-hydroxybenzoyl) -5-nitrobenzofuran can be achieved by substitution reaction with 2-butyl-3-fluoromethyl-5-nitrobenzofuran. This reaction is usually carried out under alkaline conditions, such as in the presence of sodium hydroxide, at an appropriate temperature.

Third, what is the usage of  ?  pleas see below

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2-Butyl-3- (4-hydroxybenzoyl) -5-nitrobenzofuran is an important intermediate in organic synthesis. It is widely used in the field of pharmaceuticals, for synthesizing antibiotics, antithrombotic drugs, and other drugs.

Other usages as below

Used for the synthesis of  (2-butyl-5-nitro-1-benzofuran-3-yl)-[4-[3-(dibutylamino)propoxy]phenyl]methanone  Cas no. 141645-23-0

Used for the synthesis of  N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)-benzoyl)benzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide  Cas no. 141626-57-5

Used for the synthesis of  (5-amino-2-butyl-1-benzofuran-3-yl)-[4-[3-(dibutylamino)propoxy]phenyl]methanone Cas no. 141644-91-9

Besides Safety Information of 2-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran CAS NO. 141645-16-1 is also important when handling it

What is the appearance of 2-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran CAS NO. 141645-16-1?   Please see the picture of 2-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran CAS NO. 141645-16-1, below

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Specification of 2-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran CAS NO. 141645-16-1, is below

1. Appearance: yellow to light yellow solid.

2. Melting point: 85-87 ℃.

3. Solubility: It is insoluble in water under acidic conditions, but soluble in organic solvents such as ethanol and chloroform.

Assay: 98 % min by HPLC

IR identity: conform

Water:0.5% max by K.F.

HNMR  picture of  2-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran CAS NO. 141645-16-1  is as follows,

Reference of  Article cited for your reference below,

（1）

An alternative approach to synthesis of 2-n-butyl-5-nitrobenzofuran derivative: A key starting material for dronedarone hydrochloride

Publication Date: 2012

Publication Name: Journal of Chemical Sciences

（2）

A kind of novel benzofuran derivative, preparation method and application

Publication Number: CN-106432159-B

Priority Date: 2016-07-14

Grant Date: 2019-07-12

（3）

Process for preparation of dronedarone by Grignard reaction

Publication Number: US-9238636-B2

Priority Date: 2012-05-31

Grant Date: 2016-01-19