Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate
CAS NO. 212322-56-0
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To begin with, let us tell you what is the basic information of Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate CAS NO. 212322-56-0?
Molecular Formula |
C15H18F3NO4 |
Molecular Weight |
333.303 |
Density |
1.3±0.1 g/cm3 |
Boiling Point |
443.1±45.0 °C at 760 mmHg |
Flash Point |
221.8±28.7 °C |
Melting Point |
106 °C |
Like many stuff, it has many synonyms as follows
ALA002 |
Ethyl 3-[3-Amino-4-(methylamino)-N-(2-pyridyl)benzamido]propionate |
Benzenebutanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-, (βR)- |
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate |
ethyl N-[3-amino-4-(methylamino)benzoyl]-N-pyridin-2-yl-beta-alaninate |
(3R)-3-[(tert-Butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid |
ethyl 3-[[3-amino-4-(methylamino)benzoyl](pyridin-2-yl)amino]propanoate |
β-Alanine, N-[3-amino-4-(methylamino)benzoyl]-N-2-pyridinyl-, ethyl ester |
ethyl 3-[[3-amino-4-(methylamino)benzoyl](pyridin-2-yl)amino]propionate |
Ethyl N-[3-amino-4-(methylamino)benzoyl]-N-2-pyridinyl-β-alaninate |
3-[(3-amino-4-methylamino-benzoyl)pyridin-2-yl-amino]-propionic acid ethyl ester |
3-amino-4-methylamino-benzoic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide |
Ethyl N-[3-amino-4-(methylamino)benzoyl]-N-pyridin-2-yl-β-alaninate |
3-[3-Amino-4-(methylamino)-N-(2-pyridyl)benzamido]propionic Acid Ethyl Ester |
(3R)-3-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)-4-(2,4,5-trifluorophenyl)butanoic acid |
ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate |
(3R)-N-(tert-Butoxycarbonyl)-3-amino-4-(2,4,5-; trifluorophenyl)butanoic Acid |
First, the chemical is very special, some technical indexes as below
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Module 1 chemical
Product Name: Ethyl 3- [3-Amino-4- (methylamino) - N - (2-pyridyl) benzomido] prolionate
five point three
Module 2 Hazard Overview
GHS classification
Physical hazards not classified
Health hazards not classified
Environmental hazards not classified
GHS tag elements
No icons or hazard signs
Signal word No signal word
Hazard Description None
Prevention instructions None
Module 3 Composition/Composition Information
Single substance/mixture Single substance
Chemical name (Chinese name): 3- [3-amino-4- (methylamino) - N - (2-pyridyl) benzoylamine] ethyl propionate
Percentage:>98.0% (HPLC) (T)
CAS code: 212322-56-0
Common name: 3- [3-Amino-4- (methylamino) - N - (2-pyridyl) benzamido] propionic acid Ethyl
Ester
Molecular formula: C18H22N4O3
Module 4 First aid measures
Inhalation: Move the victim to fresh air, keep breathing clear, and rest. If you feel unwell, please seek medical attention.
Skin contact: Immediately remove/remove all contaminated clothing. Wash skin/shower with water.
If skin irritation or rash occurs: seek medical attention.
Eye contact: Carefully wash with water for a few minutes. If convenient and easy to operate, remove contact lenses. Continue cleaning.
If eye irritation: seek medical attention/medical attention.
Ingestion: If feeling unwell, seek medical attention. Rinse your mouth.
Protection for emergency rescuers: Rescue workers need to wear personal protective equipment, such as rubber gloves and airtight goggles.
Module 5 Firefighting measures
Suitable extinguishing agent: dry powder, foam, atomized water, carbon dioxide
]Ethyl propionate
Module 5 Firefighting measures
Special hazard: Caution, combustion or high temperature may decompose and produce toxic smoke.
Specific method: Extinguish the fire from upwind and choose the appropriate extinguishing method based on the surrounding environment.
Non relevant personnel should evacuate to a safe place.
Once there is a fire around: If safe, remove the movable container.
Special protective equipment for firefighters: When extinguishing a fire, be sure to wear personal protective equipment.
Module 6 Leakage emergency response
Personal protective measures, protective equipment, and the use of personal protective equipment. Stay away from spills/leaks and keep upwind.
Emergency measures: The leakage area should be enclosed with safety belts and other measures to control the entry of unrelated personnel.
Environmental protection measures: Prevent entry into the sewer.
Methods and materials for control and cleaning: clean and collect dust, seal it in a closed container. Be careful not to scatter. Attached or collected materials should be immediately identified based on appropriate
Legal and regulatory disposal.
Module 7 Handling and storage
handle
Technical measures: Handle in a well ventilated area. Wear appropriate protective gear. Prevent dust diffusion. Thoroughly clean hands after handling
And face.
Attention: If dust or aerosols are generated, use local exhaust.
Precautions for handling: Avoid contact with skin, eyes, and clothing.
Storage
Storage conditions: Keep the container closed. Refrigerated storage.
Keep away from incompatible materials such as oxidants for storage.
Thermal sensitivity
Packaging materials: In accordance with the law.
Module 8 Contact control and individual protection
Engineering control: Install enclosed systems or local exhaust systems as much as possible, and operators should not come into direct contact with them. Install shower and wash simultaneously
Eye apparatus.
Personal protective equipment
Respiratory protection: Dust mask. According to local and government regulations.
Hand protection: Protective gloves.
Eye protection: Safety goggles. If necessary, wear a mask.
Skin and body protection: protective clothing. If necessary, wear protective boots.
Module 9 Physical and chemical properties
solid
Appearance (20 ° C):
Appearance: Crystal powder
Color: White - slightly light yellow
Odor: No information available
PH: No data available
Melting point:
106 ° C
Boiling point/boiling range not available
Flash point: No data available
Explosive characteristics
Lower explosive limit: No data available
Explosion limit: No data available
Density: No data available
Solubility:
[Water] No data available
]Ethyl propionate
Module 9 Physical and chemical properties
[Other solvents]
Soluble in: methanol
Module 10 Stability and reactivity
Chemical stability: Generally stable.
The possibility of dangerous reactions: No special reactivity has been reported.
Substances to be avoided from contact with oxidants
Dangerous decomposition products: carbon monoxide, carbon dioxide, nitrogen oxides (NOx)
Module 11 toxicological information
Acute toxicity: No data available
Skin corrosion or irritation: No data available
Serious damage or irritation to eyes: No data available
Germ cell variability: no data available
Carcinogenicity:
IARC=No data available
NTP=No data available
Reproductive toxicity: No data available
Module 12 Ecological information
Ecotoxicity:
Fish: No data available
Crustaceans: No data available
Algae: No data available
Residual/degradability: No data available
Potential Bioaccumulation (BCF): No data available
Mobility in soil
Log water distribution coefficient: No data available
Soil absorption coefficient (Koc): No data available
Henry's Law No data available
Constant (PaM3/mol):
Module 13 Abandoned disposal
If possible, recycle and dispose of it. Please consult the local management department. Suggest dissolving and mixing in combustible solvents, and in chemical incinerators equipped with post combustion and washing devices
Burning. Please comply with all national, regional, and local regulations when disposing of waste.
Module 14 Transportation information
UN classification: inconsistent with UN classification standards
UN number: unspecified
Module 15 Regulatory information
The Regulations on the Safety Management of Hazardous Chemicals (issued by the State Council on January 26, 2002 and revised on February 16, 2011): Targeting the safe use of hazardous chemicals
Corresponding regulations have been made for production, storage, transportation, loading and unloading, and other aspects.
]Ethyl propionate
Second, the Synthetic Route we will recommend is the most important for your reference?
First, synthesis line of Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate CAS NO. 212322-56-01 as follows
Third, what is the usage of Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate CAS NO. 212322-56-0 ? pleas see below
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Mainly used for Intermediate of dabigatran ester
Other usages as below
Used for the synthesis of ethyl 3-[[1-methyl-2-[[4-(5-oxo-2H-1,2,4-oxadiazol-3-yl)anilino]methyl]benzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate Cas no. 872728-84-2
Used for the synthesis of ethyl 3-[[2-(chloromethyl)-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate
Cas no. 1307233-94-8
Used for the synthesis of Dabigatran etexilate ,Cas no. 211915-06-9
Besides Safety Information of Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate CAS NO. 212322-56-0 is also important when handling it
Hazard Codes |
Xi |
WGK Germany |
3 |
H.S.Code: |
2933399090 |
TSCA |
Yes |
HazardClass |
IRRITANT |
What is the appearance of Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate CAS NO. 212322-56-0? Please see the picture of Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate CAS NO. 212322-56-0, below
If you need the products .Please send your inquiry to us through e-mail: info@pewax.com.cn
Specification of Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate CAS NO. 212322-56-0, is below
Apperance: off-white to Pale Beige crystal solid.
Assay: 98 % min by HPLC
IR identity: conform
Water:0.5% max by K.F.
HNMR picture of Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate CAS NO. 212322-56-0 is as follows,
Reference of Article cited for your reference below,
(1)
A process for the preparation of an intermediate of dabigatran etexilate
Publication Number: WO-2016132296-A1
Priority Date: 2015-02-18
(2)
Publication Number: WO-2016019847-A1
Priority Date: 2014-08-06
(3)
Publication Date: 2019
Publication Name: Journal of Structural Chemistry