Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate

What is Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoatee, cas no. 212322-56-0,a producer telling you the result.

CAS NO. 212322-56-0

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To begin with, let us tell you what is the basic information of Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate CAS NO. 212322-56-0?

Molecular Formula

C15H18F3NO4

Molecular Weight

333.303

Density

1.3±0.1 g/cm3

Boiling Point

443.1±45.0 °C at 760 mmHg

Flash Point

221.8±28.7 °C

Melting Point

106 °C

 

Like many stuff, it has many synonyms as follows

ALA002

Ethyl 3-[3-Amino-4-(methylamino)-N-(2-pyridyl)benzamido]propionate

Benzenebutanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro-, (βR)-

ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate

ethyl N-[3-amino-4-(methylamino)benzoyl]-N-pyridin-2-yl-beta-alaninate

 (3R)-3-[(tert-Butoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

ethyl 3-[[3-amino-4-(methylamino)benzoyl](pyridin-2-yl)amino]propanoate

β-Alanine, N-[3-amino-4-(methylamino)benzoyl]-N-2-pyridinyl-, ethyl ester

ethyl 3-[[3-amino-4-(methylamino)benzoyl](pyridin-2-yl)amino]propionate

Ethyl N-[3-amino-4-(methylamino)benzoyl]-N-2-pyridinyl-β-alaninate

3-[(3-amino-4-methylamino-benzoyl)pyridin-2-yl-amino]-propionic acid ethyl ester

3-amino-4-methylamino-benzoic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide

Ethyl N-[3-amino-4-(methylamino)benzoyl]-N-pyridin-2-yl-β-alaninate

3-[3-Amino-4-(methylamino)-N-(2-pyridyl)benzamido]propionic Acid Ethyl Ester

(3R)-3-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)-4-(2,4,5-trifluorophenyl)butanoic acid

ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate

 (3R)-N-(tert-Butoxycarbonyl)-3-amino-4-(2,4,5-; trifluorophenyl)butanoic Acid

 

First, the chemical is very special, some technical indexes as below

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Module 1 chemical

 

Product Name: Ethyl 3- [3-Amino-4- (methylamino) - N - (2-pyridyl) benzomido] prolionate

 

five point three

 

Module 2 Hazard Overview

 

GHS classification

 

Physical hazards not classified

 

Health hazards not classified

 

Environmental hazards not classified

 

GHS tag elements

 

No icons or hazard signs

 

Signal word No signal word

 

Hazard Description None

 

Prevention instructions None

 

Module 3 Composition/Composition Information

 

Single substance/mixture Single substance

 

Chemical name (Chinese name): 3- [3-amino-4- (methylamino) - N - (2-pyridyl) benzoylamine] ethyl propionate

 

Percentage:>98.0% (HPLC) (T)

 

CAS code: 212322-56-0

 

Common name: 3- [3-Amino-4- (methylamino) - N - (2-pyridyl) benzamido] propionic acid Ethyl

 

Ester

 

Molecular formula: C18H22N4O3

 

Module 4 First aid measures

 

Inhalation: Move the victim to fresh air, keep breathing clear, and rest. If you feel unwell, please seek medical attention.

 

Skin contact: Immediately remove/remove all contaminated clothing. Wash skin/shower with water.

 

If skin irritation or rash occurs: seek medical attention.

 

Eye contact: Carefully wash with water for a few minutes. If convenient and easy to operate, remove contact lenses. Continue cleaning.

 

If eye irritation: seek medical attention/medical attention.

 

Ingestion: If feeling unwell, seek medical attention. Rinse your mouth.

 

Protection for emergency rescuers: Rescue workers need to wear personal protective equipment, such as rubber gloves and airtight goggles.

 

Module 5 Firefighting measures

 

Suitable extinguishing agent: dry powder, foam, atomized water, carbon dioxide

 

]Ethyl propionate

 

Module 5 Firefighting measures

 

Special hazard: Caution, combustion or high temperature may decompose and produce toxic smoke.

 

Specific method: Extinguish the fire from upwind and choose the appropriate extinguishing method based on the surrounding environment.

 

Non relevant personnel should evacuate to a safe place.

 

Once there is a fire around: If safe, remove the movable container.

 

Special protective equipment for firefighters: When extinguishing a fire, be sure to wear personal protective equipment.

 

Module 6 Leakage emergency response

 

Personal protective measures, protective equipment, and the use of personal protective equipment. Stay away from spills/leaks and keep upwind.

 

Emergency measures: The leakage area should be enclosed with safety belts and other measures to control the entry of unrelated personnel.

 

Environmental protection measures: Prevent entry into the sewer.

 

Methods and materials for control and cleaning: clean and collect dust, seal it in a closed container. Be careful not to scatter. Attached or collected materials should be immediately identified based on appropriate

 

Legal and regulatory disposal.

 

Module 7 Handling and storage

 

handle

 

Technical measures: Handle in a well ventilated area. Wear appropriate protective gear. Prevent dust diffusion. Thoroughly clean hands after handling

 

And face.

 

Attention: If dust or aerosols are generated, use local exhaust.

 

Precautions for handling: Avoid contact with skin, eyes, and clothing.

 

Storage

 

Storage conditions: Keep the container closed. Refrigerated storage.

 

Keep away from incompatible materials such as oxidants for storage.

 

Thermal sensitivity

 

Packaging materials: In accordance with the law.

 

Module 8 Contact control and individual protection

 

Engineering control: Install enclosed systems or local exhaust systems as much as possible, and operators should not come into direct contact with them. Install shower and wash simultaneously

 

Eye apparatus.

 

Personal protective equipment

 

Respiratory protection: Dust mask. According to local and government regulations.

 

Hand protection: Protective gloves.

 

Eye protection: Safety goggles. If necessary, wear a mask.

 

Skin and body protection: protective clothing. If necessary, wear protective boots.

 

Module 9 Physical and chemical properties

 

solid

 

Appearance (20 ° C):

 

Appearance: Crystal powder

 

Color: White - slightly light yellow

 

Odor: No information available

 

PH: No data available

 

Melting point:

 

106 ° C

 

Boiling point/boiling range not available

 

Flash point: No data available

 

Explosive characteristics

 

Lower explosive limit: No data available

 

Explosion limit: No data available

 

Density: No data available

 

Solubility:

 

[Water] No data available

 

]Ethyl propionate

 

Module 9 Physical and chemical properties

 

[Other solvents]

 

Soluble in: methanol

 

Module 10 Stability and reactivity

 

Chemical stability: Generally stable.

 

The possibility of dangerous reactions: No special reactivity has been reported.

 

Substances to be avoided from contact with oxidants

 

Dangerous decomposition products: carbon monoxide, carbon dioxide, nitrogen oxides (NOx)

 

Module 11 toxicological information

 

Acute toxicity: No data available

 

Skin corrosion or irritation: No data available

 

Serious damage or irritation to eyes: No data available

 

Germ cell variability: no data available

 

Carcinogenicity:

 

IARC=No data available

 

NTP=No data available

 

Reproductive toxicity: No data available

 

Module 12 Ecological information

 

Ecotoxicity:

 

Fish: No data available

 

Crustaceans: No data available

 

Algae: No data available

 

Residual/degradability: No data available

 

Potential Bioaccumulation (BCF): No data available

 

Mobility in soil

 

Log water distribution coefficient: No data available

 

Soil absorption coefficient (Koc): No data available

 

Henry's Law No data available

 

Constant (PaM3/mol):

 

Module 13 Abandoned disposal

 

If possible, recycle and dispose of it. Please consult the local management department. Suggest dissolving and mixing in combustible solvents, and in chemical incinerators equipped with post combustion and washing devices

 

Burning. Please comply with all national, regional, and local regulations when disposing of waste.

 

Module 14 Transportation information

 

UN classification: inconsistent with UN classification standards

 

UN number: unspecified

 

Module 15 Regulatory information

 

The Regulations on the Safety Management of Hazardous Chemicals (issued by the State Council on January 26, 2002 and revised on February 16, 2011): Targeting the safe use of hazardous chemicals

 

Corresponding regulations have been made for production, storage, transportation, loading and unloading, and other aspects.

 

]Ethyl propionate

 

Second, the Synthetic Route we will recommend is the most important for your reference?

First, synthesis line of Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate CAS NO. 212322-56-01 as follows

Third, what is the usage of  Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate CAS NO. 212322-56-0  pleas see below

 

If you need the products .Please send your inquiry to us through    e-mail info@pewax.com.cn

 

Mainly used for Intermediate of dabigatran ester

 

Other usages as below

 

Used for the synthesis of ethyl 3-[[1-methyl-2-[[4-(5-oxo-2H-1,2,4-oxadiazol-3-yl)anilino]methyl]benzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate Cas no. 872728-84-2

Used for the synthesis of ethyl 3-[[2-(chloromethyl)-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate

Cas no. 1307233-94-8

Used for the synthesis of Dabigatran etexilate ,Cas no. 211915-06-9

 

Besides Safety Information of Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate CAS NO. 212322-56-0 is also important when handling it

 

Hazard Codes 

Xi

WGK Germany 

3

HSCode

2933399090

TSCA 

Yes

HazardClass 

IRRITANT

 

 

What is the appearance of Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate CAS NO. 212322-56-0?   Please see the picture of Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate CAS NO. 212322-56-0, below

 

If you need the products .Please send your inquiry to us through    e-mail    info@pewax.com.cn

 

Specification of Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate CAS NO. 212322-56-0, is below

Apperance: off-white to Pale Beige crystal solid.

Assay: 98 % min by HPLC

IR identity: conform

Water:0.5% max by K.F.

HNMR  picture of  Ethyl 3-(3-amino-4-(methylamino)-N-(pyridin-2-yl)benzamido)propanoate CAS NO. 212322-56-0  is as follows,

 

Reference of  Article cited for your reference below,

(1)

A process for the preparation of an intermediate of dabigatran etexilate

Publication Number: WO-2016132296-A1

Priority Date: 2015-02-18

(2)

Fluorine substituted dabigatran ester derivative, preparation method therefor, and pharmaceutical use thereof

Publication Number: WO-2016019847-A1

Priority Date: 2014-08-06

(3)

Synthesis, Crystal Structure, and Anti-Gastric Cancer Activity of Ethyl 3-(3-Amino-4-(Methylamino)-N-(Pyridin-2-Yl) Benzamido)Propanoate

Publication Date: 2019

Publication Name: Journal of Structural Chemistry