Ethyl 3-(2-((4-cyanophenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido

CAS NO. 211915-84-3

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To begin with, let us tell you what is the basic information of Ethyl 3-(2-((4-cyanophenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido CAS NO. 211915-84-3?

Like many stuff, it has many synonyms as follows

First, the chemical is very special, some technical indexes as below

Due to the complex structure of N-PCBMITPAAE, caution is required in its use and operation. Appropriate laboratory operating procedures should be followed, and appropriate protective measures should be taken, such as wearing protective gloves, masks, and goggles. In addition, it should be kept away from sources of fire and strong oxidizing agents, and maintain good ventilation conditions. Please manage the chemical substance properly during storage and handling to prevent accidents from occurring.

Second, the Synthetic Route we will recommend is the most important for your reference?

First, synthesis line of Ethyl 3-(2-((4-cyanophenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido CAS NO. 211915-84-3  as follows

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The preparation method of N-PCBMITPAAE is relatively complex and usually requires multi-step reactions. A common preparation method includes the following steps: first, synthesize 4-cyanoaniline and 1-methyl-1H-5-benzimidazole, and then react them with formate ketal to generate N - [(4-cyanobenzene) methyl] -1-methyl-1H-5-benzimidazol-2-carboxylate. Next, it reacts with 3-aminobenzoyl chloride to form N - [(4-cyanobenzene) methyl] -1-methyl-1H-5-benzimidazole-2-carboxylic acid 3-aminobenzoyl ester. Finally, by reacting with 2-pyridyl group- β- The final product N-PCBMITPAAE is generated from ethyl alanine.

Third, what is the usage of  3-(2-((4-cyanophenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido CAS NO. 211915-84-3 ?  pleas see below

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Usage: Anticoagulant drugs; Intermediate of the active ingredient dabigatran ester for reducing the risk of stroke and systemic embolism in patients with non valvular atrial fibrillation; Dabigatran intermediate; Dabigatran ester is a novel synthetic direct thrombin inhibitor, which is a precursor drug of dabigatran and a non peptide thrombin inhibitor. Oral absorption through gastrointestinal tract.

N-PCBMITPAAE is commonly used in the synthesis research of the chemical field. Due to its complex molecular structure and active groups, it can be used as a reagent, catalyst, or additive in organic synthesis. It can also be applied in drug research or other fields of organic chemistry, such as catalytic reactions, synthesis of heterocyclic compounds, etc.

Other usage as follows

Can be used for the synthsis of the chemical Dabigatran etexilate mesylate,Cas No.: 872728-81-9

Can be used for the synthsis of the chemical Dabigatran etexilate,    Cas No.: 211915-06-9

Besides Safety Information of 3-(2-((4-cyanophenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido CAS NO. 211915-84-3   is also important when handling it

What is the appearance of 3-(2-((4-cyanophenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido CAS NO. 211915-84-3?   Please see the picture of 2,2-diethyl-malonicaciddiethylester CAS NO. 77-25-8, below

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Specification of 3-(2-((4-cyanophenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido CAS NO. 211915-84-3, is below

1. Appearance: Colorless solid or light yellow crystal.

2.Assay: 98 % min by HPLC

3. Melting point: approximately 128-130 ° C.

4. Solubility: N-PCBMITPAAE is soluble in some organic solvents, such as dimethyl sulfoxide and dichloromethane. It is almost insoluble in water.

5. IR identity: conform

6. Water:0.5% max by K.F.

13C-NMR  picture of  3-(2-((4-cyanophenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido CAS NO. 211915-84-3  is as follows,

Reference of  Article cited for your reference below,

(1)

Dabigatran ethyl ester; 429658-95-7; Ethyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate; Dabigatran (ethyl ester); BIBR-951CL; ...

Compound CID: 446804

Neighbor Type: 2D+3D

Annotation Types Count: 5

(2)

ethyl 3-[[2-[[4-(N'-hexoxycarbonylcarbamimidoyl)anilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate; ethyl 3-[[2-[[4-[(Z)-N'-hexoxycarbonylcarbamimidoyl]anilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate; MLS006010034; KSGXQBZTULBEEQ-UHFFFAOYSA-N; HMS3655H04; ...

Compound CID: 213023

Neighbor Type: 2D

Annotation Types Count: 3

(3)

Co-crystallization of a benzimidazole derivative with carboxylic acids

Publication Date: 2016

Publication Name: Research on Chemical Intermediates