1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester

 CAS NO. 112811-71-9

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To begin with, let us tell you what is the basic information of 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester CAS NO. 112811-71-9?

Like many stuff, it has many synonyms as follows

First, the chemical is very special, some technical indexes as below

Packaging: 25kg/cardboard drum

Storage: Store in a dark and sealed place

Second, the Synthetic Route we will recommend is the most important for your reference?

First, synthesis line of 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester CAS NO. 112811-71-9 as follows

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Method:

Third, what is the usage of  1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester CAS NO. 112811-71-9 ?  pleas see below

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Main Usage:

Used for Intermediate of Gatifloxacin and Moxifloxacin Hydrochloride

Other usages as below

Can be used for the synthsis of the chemical 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinolinecarboxylic Acid ,Cas No.: 154093-72-8

Can be used for the synthsis of the chemical, 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid

Cas No.:112811-72-0 

Besides Safety Information of 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester CAS NO. 112811-71-9   is also important when handling it

What is the appearance of 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester CAS NO. 112811-71-9?   Please see the picture of 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester CAS NO. 112811-71-9, below

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Specification of 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester CAS NO. 112811-71-9, is below

Appearance: light yellow crystal powder

Assay: 98 % min by HPLC

High performance liquid chromatography with maximum single impurity ≤ 1.0% High performance liquid chromatography

Dry weight loss ≤ 0.5%, Appendix VIII L of Part II of the 2005 edition of the Chinese Pharmacopoeia

Burning residue ≤ 0.2%, Appendix VIII N of Part II of the 2005 edition of the Chinese Pharmacopoeia

Melting point 187-192 ℃ Appendix VI C of Part II of the 2005 edition of the Chinese Pharmacopoeia

IR identity: conform

Water:0.5% max by K.F.

HNMR  picture of  1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester CAS NO. 112811-71-9    is as follows,

Reference of  Article cited for your reference below,

（1）

Ethyl 1-cyclo-propyl-6,7-difluoro-8-meth-oxy-4-oxo-1,4-dihydro-quinoline-3-carboxyl-ate

Publication Name: Acta crystallographica. Section E, Structure reports online

Publication Date: 2008-10-31

PMCID: PMC2959496

PMID: 21581071

DOI: 10.1107/s1600536808034715

（2）

Ethyl 1-cyclo-propyl-6,7-difluoro-8-meth-oxy-4-oxo-1,4-dihydro-quinoline-3-carboxyl-ate

PMID 21581071; DOI 10.1107/s1600536808034715; Acta crystallographica. Section E, Structure reports online 2008 Oct; 64(Pt 11):o2214

Name matches: quinoline ethyl 1-cyclopropyl-6,7-difluoro-8-meth-oxy-4-oxo-1,4-dihydro-quinoline-3-carboxylate

（3）

A kind of detection method of related substances in moxifloxacin parent nucleus

Publication Number: CN-113820409-B

Priority Date: 2021-09-01

Grant Date: 2022-10-21