(S)-2-Benzylsuccinic acid

                                                               CAS NO. 3972-36-9

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To begin with, let us tell you what is the basic information of  (S)-2-Benzylsuccinic acid Cas No. 3972-36-9 ?

Like many stuff, it has many synonyms as follows

The chemical is very special

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Second, the Synthetic Route we will recommend is the most important for your reference?

First, synthesis line of (S)-2-Benzylsuccinic acid ,Cas No.: 3972-36-9 ,as follows

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Under the action of sodium methoxide, dimethyl succinate and benzaldehyde undergo a condensation reaction to produce dimethyl benzylidene succinate. The dimethyl ester is hydrolyzed and neutralized to obtain benzylidene succinic acid, which is catalyzed by hydrogenation under certain pressure to directly obtain S-benzylidene succinic acid

Second,synthesis line of  (S)-2-Benzylsuccinic acid Cas No.: 3972-36-9 ,as follows

Starting from its olefin structure, the desired product configuration can be obtained by hydrogenation of double bonds under appropriate reduction hydrogenation, and controlling the chirality during hydrogenation. Like other hydrogenation reactions, if the reaction effect is good, pure products can be obtained without post-treatment. It is worth noting that the following figure shows the synthesis of (R) -2-benzylsuccinic acid, but the product route for synthesizing the S configuration is also the same, except that the configuration of the chiral ligand needs to be changed

Other synthesis lines of (S)-2-Benzylsuccinic acid Cas No.: 3972-36-9 as follows？

Third, what is the usage of  (S)-2-Benzylsuccinic acid Cas No.: 3972-36-9 ?   pleas see below

Main Usage:

(S) 2-benzylsuccinic acid is a common asymmetric synthesis intermediate, in which the carboxyl group in the structure can be converted into common active functional groups, such as hydroxyl groups under the reduction of borane. In addition, the two carboxyl groups in the structure can be heated, dehydrated, and condensed in the presence of acetic anhydride or acetyl chloride to obtain the corresponding anhydride structure.

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Other usages as below

One kind of raw material for producing Mitiglinide cas no 145375-43-5,which is as follows

Besides Safety Information is also important when handling it

What is the appearance of  (S)-2-Benzylsuccinic acid Cas No.: 3972-36-9?   Please see the picture of (S)-2-Benzylsuccinic acid Cas No.: 3972-36-9  below

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Specification of (S)-2-Benzylsuccinic acid Cas No.: 3972-36-9 is below

Apperance: white or off-white crytal powder

Assay: 99 % min by HPLC

IR identity: conform

Melting Point:164~166℃

Water by KF:0.5% max.

HNMR  picture of  (S)-2-Benzylsuccinic acid Cas No.: 3972-36-9    is as follows,

Reference of  Article cited for your reference below,

(1)CAS Common Chemistry; EPA DSSTox; European Chemicals Agency (ECHA); FDA Global Substance Registra....

(2)Characterization of the inhibitor complexes of cobalt carboxypeptidase A by electron paramagnetic resonance spectroscopy

    PMID 2541781; DOI 10.1021/bi00431a042; Biochemistry 1989 Mar; 28(5):2251-8

    Name matches: beta-phenylpropionate l-benzylsuccinate