2-Piperidone
CAS NO. 675-20-7
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To begin with, let us tell you what is the basic information of 2-Piperidone
|
CAS Number |
675-20-7 |
Molecular Weight |
99.131 |
|
Density |
1.073 |
MSDS |
|
|
Molecular Formula |
C5H9NO |
Melting Point |
38-40 °C(lit.) |
|
Boiling Point |
256-262 ºC |
Flash Point |
147 ºC |
Like many stuff, it has many synonyms as follows
EINECS 211-622-9
5-pentanelactam
i-valerolactam
Valerolactam
2-oxo-piperidine
Piperidin-2-on
piperidone
a-Piperidone
6-VALEROLACTAM
Piperidone-2
Piperidon
piperidin-2-one
piperidinone
valerolactim
D-VALEROLACTAM
piperidin-1-yl-2-one
The chemical is very special,so we want to show some special properties as follows
1. Reference value for hydrophobic parameter calculation (XlogP): None
2. Number of hydrogen bond donors: 1
3. Number of hydrogen bond receptors: 1
4. Number of rotatable chemical bonds: 0
5. Number of tautomers: 3
6. Topological molecule polarity surface area 29.1
7. Number of heavy atoms: 7
8. Surface charge: 0
9. Complexity: 80.1
10. Number of Isotope Atoms: 0
11. Determine the number of atomic structure centers: 0
12. Number of uncertain atomic structure centers: 0
13. Determine the number of chemical bond stereocenters: 0
14. Number of uncertain chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Second, the Synthetic Route we will recommend is the most important for your reference?
2-Azcyclohexanone can be prepared from cyclopentanone through a two-step reaction. There are literature reports that it can be used to prepare pentolactam alkaloids and 1- (4-nitrophenyl) piperidine-2-one.
Other synthesis lines as follows？
Third, what is the usage of 2-Piperidone ? pleas see below
2-Piperidone is mainly used a kind of ketone organic compound that can be used as an organic intermediate.
A. One kind of raw material for producing methyl (2S)-2-pyrrolidinecarboxylate，cas no 2577-48-2,which is as follows
B. One kind of raw material for producing benzyl 2-oxopiperidine-1-carboxylate,cas no 106412-35-5 ,which is as follows
C.. One kind of raw material for producing 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine cas no 34167-66-3
,which is as follows
Besides Safety Information is also important when handling it
1. Acute toxicity: Rat (oral) LDLo: 11 mg/kg;
Mouse (peritoneum) LD50: ＞ 1 mg/kg
Mouse (intravenous) LD50: 600mg/kg
Toad (subcutaneous) LD50: 3mg/kg
Due to the LD50 of 3000 mg/kg of table salt, the acute toxicity of BPA is the same as that of table salt.
2. Acute toxicity:
Oral LDLo 11mg/kg (rat)
Main irritant effects:
On the skin: May cause inflammation
On the eyes: May cause inflammation
Sensitization: No known sensitization effect
Storage method
Store in a sealed container and place in a cool, dry place. The storage area must be kept away from oxidants.
Dangerous Goods Sign Xi
Hazard category codes 36/37-36/37/38
Safety instructions 22-24/25-37/39-26-26
WGKGermany 3
RTECS number TO0110000F3-10TSCAYes
Customs code 29337900.90
What is the appearance of it ? Please see the picture of 2-Piperidone below
Specification of it is below
Apperance: off-white powder
Assay: 99% min by HPLC
HNMR picture of 2-Piperidone cas no. 675-20-7 is as follows,
IR picture of 2-Piperidone cas no. 675-20-7 is as follows,
Reference of Article cited for your reference below,
(1)2-Piperidinone (2-piperidone or δ-valerolactam) is a chemical compound classified as a lactam. It is the monomer of
Nylon 5, a polyamide. It is used as an intermediate in the preparation of other chemicals........
(2)Some heterocycles contain no carbon. Examples are borazine (B3N3 ring), hexachlorophosphazenes (P3N3 rings), and tetrasulfur tetranitride S4N4. In comparison with organic heterocycles, which have numerous commercial applications, inorganic ring systems are mainly of theoretical interest. IUPAC recommends the Hantzsch-Widman nomenclature for naming heterocyclic compounds.[5]
(3)2-Piperidinone is a derivative of piperidine .....................
